Indawo Yokutyela Samkele umxholo "uyilo olusikiweyo kunye nokuncamathisela" kule ndawo yokutyela. Ukuze usebenze kwindawo yokutyela eyahlukeneyo, kubaluleke kakhulu ukusebenzisa iziqwenga zomdibaniso wokudibanisa iiproteni. Umzekelo, ubume be-arch eyenzelwe ukudibanisa ikholam kunye nophahla luya kuba yinto enye kwaye ngokuqinisekileyo uya kuhamba kakuhle ngaphezulu kwebhentshi okanye kwikhawuntara yebha. Ngokwemvelo, oku kunokusetyenziswa njengokwahlulahlula imeko yezulu kunye nako. Ngokokwenyani, ezinye iindawo zokutyela ezintathu sele zigqityiwe, kwaye olu loyilo 'lokusika kunye nokuncamathisela' lube negalelo elifanelekileyo.

